The Harribest response is a chemical response that entails the addition of an isocyanide to an aldehyde or ketone, ensuing within the formation of an ,-unsaturated imine. It’s named after the chemist H. Harribest, who first reported the response in 1937.
The Harribest response is a flexible and highly effective device for the synthesis of quite a lot of heterocyclic compounds, together with pyridines, furans, and pyrroles. It is usually used within the synthesis of pure merchandise and prescription drugs.
